Brugada Syndrome
The association

For patients with the Brugada syndrome a number of drugs are contraindicated or to avoid.

On the website www.brugadadrugs.org you can look up a regularly updated list of these drugs. In any case, this list should be discussed with your treating cardiologist. 

DRUGS TO BE AVOIDED :


Antiarrhythmic drugs*: Ajmaline, Allapinine, Ethacizine, Flecainide, Pilsicainide, Procainamide, Propafenone


Psychotropic drugs: Amitriptyline, Clomipramine, Desipramine, Lithium, Loxapine, Nortriptyline,Oxcarbazepine, Trifluoperazine


Anesthetics / analgesics*: Bupivacaine, Procaine, Propofol


Other substances: Acetylcholine, Alcohol (toxicity), Cannabis, Cocaine, Ergonovine


*For advice please visit www.brugadadrugs.org/emergencies


DRUGS PREFERABLY AVOIDED:


Antiarrhythmic drugs: Amiodarone, Cibenzoline, Disopyramide, Lidocaine*, Propranolol, Verapamil,Vernakalant


Psychotropic drugs: Bupropion, Carbamazepine, Clothiapine, Cyamemazine, Dosulepine, Doxepine,Fluoxetine, Fluvoxamine, Imipramine, Lamotrigine, Maprotiline, Paroxetine, Perphenazine,Phenytoin, Thioridazine


Anesthetics / analgesics: Ketamine, Tramadol


Other substances: Demenhydrinate, Diphenhydramine, Edrophonium, Indapamide, Metoclopramide,Terfenadine/Fexofenadine
* Lidocaine use for local anesthesia (e.g. by dentists) does seem to be safe if the amount administrated is low and if it is combined with adrenaline (epinephrine) which results in a local effect only.


Further, in case of fever, close (electrocardiographic) monitoring is appropriate in combination with
lowering of the body temperature (e.g. by using Paracetamol/Acetaminophen).
Please be aware of the active drugs in medicines that contain a combination of drugs. Further, the
presence or absence of a particular drug on this list do not preclude a certain harmful or safe use of
that particular drug in this patient respectively.
For the most recent recommendations (and the disclaimer) on drugs to be avoided by Brugada
syndrome patients, please visit http://www.brugadadrugs.org .

January 2015


Creation date : 07/04/2012 22:51
Last update : 13/05/2014 21:58
Category : Brugada Syndrome - Contraindicated drugs
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Reactions to this article

Reaction #3 

by webmestre 02/11/2012 23:45

Petite précision sur le buflomedil, il a en effet été retiré de la vente le 18 février 2011 par l'Afssaps, car, il pouvait entrainer des troubles du rythme cardiaque.
Merci à Bernard pour nous avoir communiqué cette info.

Reaction #2 

by gigbik 24/10/2012 17:52

bonjour
j'ajouterait a cette liste l'aotal , par experience personnel ( brugada type I ) , utilisé pour le sevrage alcoolique .
merci
v
dom

Reaction #1 

by bernard 10/09/2012 20:58

j'ajouterai le "BUFLOMEDIL" un dilatateur qui peut provoquer des troubles du rythme



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