Brugada Syndrome
The association

For patients with the Brugada syndrome a number of drugs are contraindicated or to avoid.

On the website you can look up a regularly updated list of these drugs. In any case, this list should be discussed with your treating cardiologist. 


Antiarrhythmic drugs*: Ajmaline, Allapinine, Ethacizine, Flecainide, Pilsicainide, Procainamide, Propafenone

Psychotropic drugs: Amitriptyline, Clomipramine, Desipramine, Lithium, Loxapine, Nortriptyline,Oxcarbazepine, Trifluoperazine

Anesthetics / analgesics*: Bupivacaine, Procaine, Propofol

Other substances: Acetylcholine, Alcohol (toxicity), Cannabis, Cocaine, Ergonovine

*For advice please visit


Antiarrhythmic drugs: Amiodarone, Cibenzoline, Disopyramide, Lidocaine*, Propranolol, Verapamil,Vernakalant

Psychotropic drugs: Bupropion, Carbamazepine, Clothiapine, Cyamemazine, Dosulepine, Doxepine,Fluoxetine, Fluvoxamine, Imipramine, Lamotrigine, Maprotiline, Paroxetine, Perphenazine,Phenytoin, Thioridazine

Anesthetics / analgesics: Ketamine, Tramadol

Other substances: Demenhydrinate, Diphenhydramine, Edrophonium, Indapamide, Metoclopramide,Terfenadine/Fexofenadine
* Lidocaine use for local anesthesia (e.g. by dentists) does seem to be safe if the amount administrated is low and if it is combined with adrenaline (epinephrine) which results in a local effect only.

Further, in case of fever, close (electrocardiographic) monitoring is appropriate in combination with
lowering of the body temperature (e.g. by using Paracetamol/Acetaminophen).
Please be aware of the active drugs in medicines that contain a combination of drugs. Further, the
presence or absence of a particular drug on this list do not preclude a certain harmful or safe use of
that particular drug in this patient respectively.
For the most recent recommendations (and the disclaimer) on drugs to be avoided by Brugada
syndrome patients, please visit .

January 2015

Creation date : 07/04/2012 22:51
Last update : 13/05/2014 21:58
Category : Brugada Syndrome - Contraindicated drugs
Page read 13085 times

Reactions to this article

Reaction #3 

by webmestre 02/11/2012 23:45

Petite précision sur le buflomedil, il a en effet été retiré de la vente le 18 février 2011 par l'Afssaps, car, il pouvait entrainer des troubles du rythme cardiaque.
Merci à Bernard pour nous avoir communiqué cette info.

Reaction #2 

by gigbik 10/12/2017 17:15

j'ajouterait a cette liste l'aotal , par experience personnel ( brugada type I ) , utilisé pour le sevrage alcoolique .


Reaction #1 

by bernard 10/09/2012 20:58

j'ajouterai le "BUFLOMEDIL" un dilatateur qui peut provoquer des troubles du rythme

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